Senior Scientist in Next-Gen IO

Gaithersburg, Maryland

This job has expired.

Senior Scientist in Next-Gen IO

Location: Gaithersburg MD

At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We're passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.

AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death.

We are seeking a highly motivated Senior Scientist in the Next-Gen Immuno-Oncology team with strong scientific and broad technical expertise in human immunology to join our team in Gaithersburg, MD. The NextGen IO department within ICC (Immuno-Oncology, Immune Circuits & Engagers and Cell Therapy) of Early Oncology R&D at AstraZeneca develops immunotherapies targeting cancer that boost the immune responses seen in tumors. This department is researching novel immune mechanisms that lead to a dysfunctional immune state within tumors with the aim of developing next generation therapies that reverse such dysfunctional states. Our research has a broad scope involving innate and adaptive immune cells and exploring dysfunction in metabolic pathways, antigen presentation, and antigen receptor signaling. As member of NextGen IO group, you will develop, design, conduct and analyze in vitro experiments to assess novel immunological mechanisms that can be exploited to enhance anti-tumor immunity.

This is primarily a bench scientist role and proficiency in techniques for the analysis of human immune function is crucial for this role. We are seeking a self-motivated and passionate individual with a strong lab/practical background in in vitro human immunology who is passionate about novel approaches to drug discovery. Furthermore, the individual will be expected to work in a team and in a cross-functional matrix environment as the project advances through the drug discovery pipeline.

About Our Gaithersburg Oncology Hub

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Main Duties and Responsibilities

Working within the Next-Gen IO team, you will apply your technical and scientific experience to design, conduct, and analyze in vitro experiments using primary human immune cells for enhancing anti-tumor immune responses. You will be involved in designing and performing small scale screens to identify potential immunomodulatory drug candidates. You will stay up to date with the latest discoveries in immunology and immuno-oncology, share your expertise both within and beyond the Next-Gen IO group. You will also stay up to date with new technologies and assay formats for evaluation of human immune function. You will present findings in multiple group and departmental meetings. You will be expected to maintain accurate electronic records of experiments and ensure that your own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal and external regulations and standards.

Essential Education, Skills and Experience Required

  • Ph.D. in Immunology, or other related scientific discipline and with 0-3 years post-doctoral and/or industry experience in related areas.
  • Strong background and experience in immunology with a good publication record. Experience in T cell biology is highly desired.
  • Proficiency in culturing primary human immune cells (T cells, NK cells and myeloid cells)
  • Experience with T cell functional assays such as mixed lymphocyte reactions, antigen-specific T cell responses, T cell/NK cell-dependent cytotoxicity experiments, and T cell exhaustion assays.
  • Extensive experience with multi-color flow cytometry including panel design, staining fluency, compensation, and data analysis
  • Experience with multiplex cytokine assays as well as intracellular cytokine staining by flow cytometry
  • Proficiency using Excel, GraphPad Prism, and FlowJo for data analysis
  • Excellent written and oral communication skills
  • The ability to work in a team and to collaborate across departments.

Preferred Skills and Experience
  • Knowledge of CRISPR mediated gene editing of primary immune cells.
AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: June 24, 2022

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results - pymetrics will not be used solely in our decision-making process but will help us gather additional insight.

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