Scientist - Mass Spectrometry/Peptide Mapping

Gaithersburg, Maryland

This job has expired.

AstraZeneca has taken critical steps to protecting colleagues, loved ones, and patients from COVID-19 and its variants. Accordingly, AstraZeneca requires all US employees to be fully vaccinated for COVID-19 prior to the first date of employment. AstraZeneca will consider requests for reasonable accommodations as required by applicable law.

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration through scientific research. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity.

Job Summary:

We are seeking to recruit a Scientist to join Physicochemical Development Department. In this role you will be will be responsible for analytical method development and structure characterization of biopharmaceutical products, such as enzymes, peptides, monoclonal antibodies, antibody-drug conjugates, bispecific antibodies, fusion proteins. You will lead the development and improvement of analytical methods, which include, but are not limited to HPLC/UPLC and/or CE. The Scientist will be expected to design, execute and document laboratory studies for supporting process development, clinical trial and product license application.

Primary Responsibilities:

This role will carry out a variety of analytical techniques with emphasis on peptide mapping analysis for variety of biopharmaceutical products, such as humanized monoclonal antibodies, antibody-drug conjugates, and recombinant proteins. The Scientist will be exposed to Chromatography, Mass Spectrometry and Electrophoresis techniques in supporting development, manufacturing, and characterization of products and will make detailed experimental observations, review and analyze data, and might need to interpret experimental results, and summarize data for presentations and reports. You will have opportunity to author/revise SOPs, protocols, reports and other relevant documentation.


Hands on experience of peptide mapping assay.

Relevant industry and technology experience as well as a background in protein chemistry.

Great teamwork and communication skills, both verbal and written, are critical.

Good multi-tasking, time management and organizational skills are required.

The ability to follow SOPs, policies, and regulations, and to perform routine lab equipment maintenance is required.

Ability to work in a team environment, attention to detail and strong verbal and written communication skills are also necessary.

Experience on chromatography (SEC, IEC, RPLC, GC), and/or electrophoresis (cIEF, CE-SDS) is a plus


Master's degree or PhD in Biology, Chemistry or Biochemistry


Scientist: MS with 2+ years of BioPharma experience

Special Skills/Abilities: Familiarity with data analysis software such as Protein Metrics, MassHunter, MassLynx, Empower, and OpenLab, is desirable.

o Hands-on experience in analysis of proteins, peptides and glycans with analytical methods such as SEC, RP, IEX, HIC, HILIC, CE-SDS, cIEF, CZE.

o Method development and optimization experience

o Hands-on experience in robustness evaluation of HPLC and/or CE methods

o Detail-oriented and capable of identifying and solving scientific problems.

o Ability to work independently in a fast-paced environment and drive multiple projects simultaneously.

o Strong interpersonal skills, excellent oral and written communication skills, good documentation skill.

o Good multi-tasking, time management and organizational skills are essential.

o Experience with N- and O-glycan characterization is a strong plus.

o Experience with LC-MS analysis of peptides and proteins is a plus.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

Follow AstraZeneca on Facebook

Follow AstraZeneca on Instagram

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