Scientist - Cancer Biology
AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies.

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world! This campus employs more than 3,500 professionals in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all crafted to encourage collaboration and cross-functional science. We believe employees benefit from being challenged and encouraged at work. We are dedicated to crafting a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based workspaces to suit a variety of working styles while growing collaboration between teams.

Join a dedicated Oncology team that's growing fast and building a strong track record of success.

Main Responsibilities

You will work in a laboratory within the Oncology Research & Development group designing, conducting and analyzing in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel therapeutics. You will also review emerging literature and internal data to identify new targets and contribute to target validation activities.

Essential Requirements

• Bachelor of science or master's degree in cancer biology, immunology, or a related field
  
• Depth of understanding of solid tumor and hematological cancer models, with a focus on using these models for immune-oncology research
  
• Experience with a range of in vitro skills for the analysis of human tumor cell function (e.g. cell culture, cell signaling bioassays, high-content imaging, and cell death measurement in primary and cell line cultures)
  
• Experience conducting multi-spectral flow cytometry and visualizing/quantitating high content multi-parameter flow data
  
• Molecular biology skills including creation of engineered cell lines, assessment of intracellular signaling, and generation transcriptomic data and its analysis
  
• Strong interpersonal and collaboration skills together with evidence of having used these to support problem solving and delivery in a collaborative environment.
  

Desirable Requirements

• Working with primary human immune cells, with experience in the evaluation of immune function and the application of complex immunological assays
  
• Previous work with in vivo cancer models and ex-vivo immunological assays
  
• Experience working with biologics including antibodies and antibody-drug conjugates
  
• Knowledge of the drug discovery process and experience working as part of a drug development team in academia or in the biotechnology/pharmaceutical industry
  
• Authorship on publications in credible scientific journals
  

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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